Aceclofenac 100 mg, Paracetamol 325 mg, Chlorzoxazone 250 mg tablet Use, Indication, Side Effects, Dosage, Mechanism of Action, Price, Contra-Indications, Drug Interactions...

HETROFEN MR Tablet 

Aceclofenac 100 mg, Paracetamol 325 mg,Chlorzoxazone 250 mg tablet (FC)

Hetrofen MR Tablet is a combination medication:

• Aceclofenac (100 mg): A non-steroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation.

• Paracetamol (325 mg): An analgesic and antipyretic that alleviates pain and reduces fever.

• Chlorzoxazone (250 mg): A muscle relaxant that helps relieve muscle spasms and stiffness.

Uses and Indications:

Hetrofen MR is prescribed for:

• Muscular pain and spasms

• Joint pain and inflammation

• Postoperative pain

• Conditions like osteoarthritis and rheumatoid arthritis

Mechanism of Action:

• Aceclofenac inhibits cyclooxygenase enzymes, decreasing the production of prostaglandins, thereby reducing inflammation and pain.

• Paracetamol acts centrally in the brain to elevate the pain threshold and reduce fever.

• Chlorzoxazone works on the central nervous system to relax muscles and alleviate spasms.

Dosage and Administration:

• Take the tablet as directed by your doctor, with or without food.

• Swallow the tablet whole; do not chew or crush.

• The usual dosage is one tablet twice daily, but follows your doctor's instructions.

Side Effects:

Common side effects may include:

• Nausea and vomiting

• Stomach pain and indigestion

• Dizziness and drowsiness

• Diarrhea

• Loss of appetite

Consult your doctor if these persist or worsen.

Contraindications:

Do not use Hetrofen MR if you have:

• Hypersensitivity to any of its components

• Active or history of gastrointestinal ulcers or bleeding

• Severe liver or kidney impairment

• Pregnancy (especially in the third trimester)

Drug Interactions:

• Paracetamol: May interact with alcohol, barbiturates, carbamazepine, hydantoins, isoniazid, rifampin, and sulfinpyrazone, increasing the risk of liver damage.

• Aceclofenac: May increase plasma concentrations of lithium and digoxin, enhance the activity of anticoagulants, and increase plasma methotrexate levels leading to toxicity if administered within 2–4 hours of methotrexate administration.

• Chlorzoxazone: May enhance the sedative effects of alcohol and other central nervous system depressants.

For Use of Registered Medical Practitioner or A Hospital Only

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