Aceclofenac 100 mg, Paracetamol 325 mg Tablet Use, Indication, Side Effects, Dosage, Mechanism of Action, Price, Contra-Indications, Drug Interactions...

HETROFEN P Tablet

Aceclofenac 100 Mg, Paracetamol 325 Mg Tablet 

HETROFEN P Tablet contains a combination of Aceclofenac (100 mg) and Paracetamol (325 mg). This combination is typically used to manage pain and inflammation.

Use (Indication):

HETROFEN P Tablet is primarily indicated for:

• Pain Relief: Used to relieve mild to moderate pain, such as headaches, toothaches, muscle pain, or post-surgical pain.

• Anti-inflammatory Effects: It is used for conditions that involve inflammation, such as osteoarthritis, rheumatoid arthritis, and other inflammatory joint disorders.

• Fever Reduction: Paracetamol (acetaminophen) helps reduce fever and can also be used in conditions where fever is present alongside pain.

Mechanism of Action:

• Aceclofenac:
  Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID). It works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, which are involved in the production of prostaglandins. Prostaglandins are chemicals in the body that promote inflammation, pain, and fever. By inhibiting these enzymes, Aceclofenac helps reduce inflammation and pain.

• Paracetamol (Acetaminophen):
  Paracetamol works primarily in the central nervous system (CNS). It inhibits the enzyme COX in the brain (specifically COX-3), leading to pain relief and a reduction in fever. Unlike NSAIDs, Paracetamol does not have significant anti-inflammatory effects.

Dosage:

• Adults:
  The typical dose is 1 tablet twice a day. The exact dosage should be adjusted based on the specific condition and doctor's advice.

• Children:
  Not typically recommended for children under 12 years unless directed by a doctor.

Side Effects:

Common side effects can include:

• Gastrointestinal:

  • Nausea, vomiting, or abdominal discomfort

  • Risk of gastrointestinal bleeding or ulcers (especially with long-term use of Aceclofenac)

• Liver and Renal Effects:

  • Elevated liver enzymes

  • Renal impairment or kidney-related issues (more common in long-term use or in patients with preexisting kidney conditions)

• Allergic Reactions:

  • Rash, itching, swelling, or hives

  • In rare cases, severe allergic reactions (anaphylaxis) may occur.

• Other:

  • Dizziness or headache

  • Sleep disturbances

Serious side effects (though rare) could include liver failure, gastrointestinal bleeding, and severe allergic reactions.

Contraindications:

HETROFEN P Tablet should not be used in the following cases:

• Allergy to Aceclofenac, Paracetamol, or any NSAIDs (e.g., aspirin)

• Active gastrointestinal bleeding or history of peptic ulcers

• Severe liver or kidney impairment

• Severe heart failure or other significant cardiovascular conditions

• Pregnancy (especially in the third trimester) and breastfeeding, unless directed by a doctor

• Asthma or rhinitis caused by NSAIDs

• Blood disorders (e.g., thrombocytopenia, anemia)

Drug Interactions:

• Aceclofenac:

  • Anticoagulants (e.g., warfarin): Increases the risk of bleeding.

  • Diuretics (e.g., furosemide): Can reduce the effectiveness of diuretics and may increase the risk of kidney problems.

  • Antihypertensives (e.g., ACE inhibitors): Can reduce the effectiveness of blood pressure medications.

  • Other NSAIDs: Using multiple NSAIDs together can increase the risk of gastrointestinal side effects or kidney problems.

• Paracetamol:

  • Alcohol: Excessive alcohol consumption increases the risk of liver damage when taking paracetamol.

  • Anticoagulants: Long-term use of paracetamol may enhance the effects of anticoagulants like warfarin.

  • Other liver-metabolized drugs: Overuse of paracetamol with other liver-metabolized medications can increase the risk of liver toxicity.

For Use of Registered Medical Practitioner or A Hospital Only

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